I have been through most bits but only knew a few areas well. East London obviously as I work there and have to move about it. The route from there to Paddington via Madame Tussauds and Sherlock Holmes house as I was dropping my ex off to get the train to welsh Wales (St Clears) or to work at the waxworks regularly. And the route along the river to cut through to the M3 when I was travelling to Devon a lot on the bike.
Anything else I was usually lost. The last time I was lost about 18 months ago I saw Buckingham Palace, a lay down protest by cyclists in Parliament, riot police running to another row about race and St Pauls Cathedral before I found my way back to east London.